Uric acid is one of the end product of purine metabolism. The man constantly produces uric acid in all its body cells. It results in degradation and remodeling processes, the so-called physiological cell degradation. The human body consists of approximately 100 thousand billion cells. Since a lot of uric acid is produced. With the blood uric acid then enters the kidney and intestine. There it is filtered out and excreted. Purines are part of the genetic information contained in every animal and plant cell. Here, the higher an organism is developed, the more genetic material in cells is needed to store all information. When plants are not the reason why so many, such as in advanced mammals and humans. This impacts on the diet. Those who eat lots of meat, takes up a lot more purines, which must then be broken down into uric acid. This relationship also plays a crucial role in gout.
The purine metabolism uric acid from the metabolism in our cells and the purines from the diet are converted to a degradation process to hypoxanthine. With the help of the enzyme xanthine oxidase is hypoxanthine to xanthine to uric acid, and finally processed. Our body excretes daily from about 400 to 800 mg of uric acid in the urine. The process of uric acid metabolism can be found depicted in the image opposite. This mechanism is disturbed in any way, can produce uric acid in the blood and accumulate in the urine.
Uric acid stones form in acidic urine
An increased excretion of uric acid is called hyperuricaemia. Uric acid stones occur in about 5 to 10 percent of those affected by a stone in front. The main cause for the formation of uric acid stones is an acidic urine with a pH below 5.8. Overall, the increase in uric acid in urine following reasons:
increased accumulation of purines.
in the organism when it comes to increased cell death, eg In certain diseases such as leukemia, hemolytic anemia, psoriasis, or a tumor during chemotherapy.
through increased supply of animal protein foods such as purinhaltigen or beer (see gout: 1 / 3 of all gout patients develop uric acid stones.
excretion of uric acid induced renal failure, eg by medications or by kidney disease.
The serum concentration of uric acid without urine is no increased risk
In people who have an elevated uric acid in the blood, the urine is not acidic but no increased risk for uric acid stone formation. Crucial to the uric acid stone formation is the urine, because the result is that uric acid can not dissolve in urine, but forms as undissociated uric acid crystals. This can cause can develop despite a normal total uric acid excretion in very acidic urine uric acid stones.
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